Emery Haley, PhD, Scientific Writing Specialist
Ceftazidime
Find the Latest FDA-Approved Labelling Information Here: Drugs@FDA Online Database
Administrative Routes
Parenteral [intravenous infusion (IV), intramuscular injection (IM)]
Other Names
Rocephin
Bacteriostatic or Bactericidal
Bactericidal [1]
Antibiotic Class
Third-Generation Cephalosporin
Mechanisms of Action
Ceftriaxone, a beta-lactam antibiotic, binds to penicillin-binding proteins (PBPs) on bacterial cell walls. PBPs are essential for the formation of peptidoglycan, which gives the bacterial wall strength and integrity. Binding of ceftriaxone to PBPs leads to failure of peptidoglycan cell wall synthesis, causing bacterial cell death.
WHO AWaRe Classification
Watch [2]
Empiric Use Recommendations
Yes (upper UTI/pyelonephritis) [World Health Organization (WHO)] [3]
Yes (preferred for complicated UTI with or without sepsis) [Infectious Diseases Society of America (IDSA)] [4]
Indication(s) Relevant to UTI
On label for both uncomplicated and complicated UTIs caused by the following organisms included in the Guidance® UTI test: Escherichia coli, Proteus mirabilis, Morganella morganii, or Klebsiella pneumoniae.
Checkmarks
CLSI and/or FDA documents support the efficacy of this antibiotic against the following organisms from the Guidance® UTI test: Acinetobacter baumannii, Aerococcus urinae, Citrobacter koseri, Corynebacterium riegelii, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Proteus mirabilis, Streptococcus agalactiae, and Viridans Group Streptococci.
Published primary literature supports the efficacy of this antibiotic against the following organisms from the Guidance® UTI test: Alloscardovia omnicolens [5] and Actinotignum schaalii [6-8]