Pooled antibiotic susceptibility testing that evaluates how antibiotics perform against the infection as a whole — including in polymicrobial cases. Results in 24–36 hours.
A library covering the organisms and antibiotics on the Guidance® UTI panel — why each is clinically relevant and why it earned a place in targeted treatment decisions.
The Importance of a Comprehensive UTI Panel Urinary tract infections (UTIs) are among the most common bacterial infections. They affect millions of people each year. Standard urine cultures often miss key pathogens or fail to provide timely
Read moreMargo Lee, Ph.D. The emergence of antimicrobial resistance (AMR) poses a global health crisis that affects our ability to treat many common infectious diseases. The rise of antibiotic-resistant pathogens has created challenges in treating p
Read moreHuman papillomavirus (HPV) is one of the most common causes of sexually transmitted diseases worldwide. It has been proposed that the great majority of women and men have been infected with HPV at least once during their lifetime. HPV infec
Read moreIn the United States, human papillomavirus (HPV) and Papanicolaou (Pap) testing (cotesting) for cervical screening in women ages 30 to 65 years is the preferred strategy, and cytology alone is acceptable. Recently, a proprietary automated t
Read moreWe investigated this very question by retrospectively reviewing the hospitalization/ED visit rate of 66,383 patients who were either treated against Standard Urine Culture or Guidance-UTI. The cohort which was treated using Guidance UTI ill
Read moreStudies have shown that multiple genes influence antibiotic susceptibility, but the relationship between genotypic and phenotypic antibiotic susceptibility is unclear. In this paper, we analyzed the concordance between the presence of antib
Read moreThis study was designed to further compare the performance of Multiplex-Polymerase Chain Reaction (M-PCR) relative to Standard Urine Culture (SUC) in the urology practice. The study included over 2,500 elderly patients presenting with sympt
Read moreAntimicrobial sensitivity protocols are standardized for monomicrobial infections; however, the standard methods do not consider bacterial interactions that impact susceptibility results. In this study, antibiotic susceptibility patterns we
Read moreGuidance® UTI: Personalized Therapy Options from Sample to Result in Less than One Day Urinary Tract Infections (UTIs) can cause many potentially life-threatening complications, with approximately 25% of all adult sepsis cases resulting fro
Read moreGuidance® UTI Associated with a 13.7% Reduction in Hospitalization The health care industry is focused more than ever on reducing hospital visits and admissions.Results from a new study byPathnostics® titled “Utilization of M-PCR and P-AST™
Read moreMargo Lee, Ph.D. Bacterial organisms coexist as multispecies communities in nature. These communities can range from a couple of bacteria to millions of microorganisms assembled in a complex, dynamic environment. Many species in these commu
Read moreThe current diagnostic standard procedure outlined by the Health Protection Agency for urinary tract infections (UTIs) in clinical laboratories does not report bacteria isolated from samples containing three or more different bacterial spec
Read moreHow you can manage costs without losing quality A Better Way to Detect Bladder Cancer ProExC labels the cell cycle proteins, minichromosome maintenance protein-2 (MCM2) and topoisomerase II-a (TOP2A). MCM2 belongs to the DNA licensing facto
Read moreThis retrospective study was designed to determine if Multiplex-Polymerase Chain Reaction (M-PCR) is safe to use in the urology practice. The test results of 582 elderly patients presenting with symptoms of lower urinary tract infections fr
Read morePCR testing for UTI’s may not tell the whole story. Polymerase Chain Reaction (PCR) testing is often utilized to identify the organisms found when Urinary Tract Infection (UTI) testing is performed. Results from PCR testing are intended to
Read moreMargo Lee, Ph.D. Standard urine culture (SUC) is a laboratory test first standardized in the 1950s to diagnose urinary tract infections.1 The test is performed by using a urine specimen from a patient and placing it in a culture environment
Read moreMedicare database analysis presented at the 2022 American Urology Association Meeting found 44% lower total costs and 77% lower clinically-advanced costs with Guidance UTI versus standard urine culture (SUC) IRVINE, Calif., May 14, 2022 /PR
Read moreRecurrent urinary tract infections (UTIs) present a significant health issue for women, with uncomplicated UTI occurring in at least 50% of women, and about 30% experiencing recurrent UTI (rUTI).1–3 Although there are multiple definitions f
Read moreThe rate of polymicrobial infections, or infections involving two or more micro-organisms, is as high as 39% in urinary tract infections (UTI) (1). How can polymicrobial infections form in the urinary tract? Years of clinical research have
Read moreMargo Lee, Ph.D. Urinary tract infections (UTIs) are common infections that are caused by bacteria that inhabit the kidneys, bladder, ureter, or urethra.1 These infections effect more than 150 million people globally per year and account fo
Read moreCytology is an excellent method with which to diagnose preinvasive lesions of the uterine cervix, but it suffers from limited specificity for clinically significant lesions. Supplementary methods might predict the natural course of the dete
Read moreIncreased levels of AMACR (P504S) protein concentration and activity are typically associated with prostate cancer, used widely as a biomarker in prostate biopsy tissues. In recent years, many studies have also identified AMACR as a useful
Read moreDo you value having antibiotic sensitivity testing results when deciding on treatment options for your recurrent or complicated UTI patients? You know the importance of understanding both phenotypic and genotypic information in these infect
Read moreCervical cancer screening test performance has been hampered by either lack of sensitivity of Pap cytology or lack of specificity of Human Papillomavirus (HPV) testing. This uncertainty can lead to unnecessary referral and treatment, which
Read moreEnhanced quantitative urine culture (EQUC) detects live microorganisms in the vast majority of urine specimens reported as “no growth” by the standard urine culture protocol. Here, we evaluated an expanded set of EQUC conditions (expanded-s
Read moreIt took nearly 2,500 years to get past the cutting edge practice of tasting urine to diagnose diseases. It has taken less than 150 years to advance from tasting urine, to clinical culture, and on to molecular diagnostics. Hippocrates (460 –
Read moreOur previous study showed that bacterial genomes can be identified using 16S rRNA sequencing in urine specimens of both symptomatic and asymptomatic patients who are culture negative according to standard urine culture protocols. In the pre
Read moreTalk to a Pathnostics representative about Guidance® UTI and our other tests.