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Guidance® UTI Publications

Urine Biomarkers Individually and as a Consensus Model Show High Sensitivity and Specificity for Detecting UTIs

BMC Infectious Diseases. Published 31 January, 2024.
Authors: Marzieh AkhlaghpourEmery HaleyLaura ParnellNatalie LukeMohit MathurRichard A FestaMichael PercaccioJesus MagallonMariana Remedios-ChanAlain RosasJimin WangYan JiangLori AndersonDavid Baunoch

The Prevalence and Association of Different Uropathogens Detected by M-PCR with Infection-Associated Urine Biomarkers in Urinary Tract Infections

Research and Reports in Urology. Published 9 January, 2024.
Authors: Emery Haley, Natalie Luke, Mohit Mathur, Richard A. Festa, Jimin Wang, Yan Jiang, Lori Anderson, David Baunoch

Emerging and Fastidious Uropathogens Were Detected by M-PCR with Similar Prevalence and Cell Density in Catheter and Midstream Voided Urine Indicating the Importance of These Microbes in Causing UTIs

Infection and Drug Resistance. Published 23 December, 2023.
Authors: Dakun Wang, Emery Haley, Natalie Luke, Mohit Mathur, Richard A Festa, Xinhua Zhao, Lori A Anderson, Jennifer L Allison, Kristen L Stebbins, Manuel Jose Diaz, David Baunoch

Comparison Shows that Multiplex Polymerase Chain Reaction Identifies Infection-associated Urinary Biomarker–positive Urinary Tract Infections That Are Missed by Standard Urine Culture

European Urology Open Science. Published December 2023.
Authors: Emery Haley, Natalie Luke, Mohit Mathur, Richard A. Festa, Jimin Wang, Yan Jiang, Lori Anderson, David Baunoch

Improving Patient Outcomes While Reducing Empirical Treatment with Multiplex-Polymerase-Chain-Reaction/Pooled-Antibiotic-Susceptibility-Testing Assay for Complicated and Recurrent Urinary Tract Infections

MDPI. Published 26 September, 2023.
Authors: Emery Haley, Natalie Luke, Howard Korman, David Baunoch, Dakun Wang, Xinhua Zhao and Mohit Mathur.

Elevated UTI Biomarkers in Symptomatic Patients with Urine Microbial Densities of 10,000 CFU/mL Indicate a Lower Threshold for Diagnosing UTIs

Diagnostics. Published 16 August, 2023.
Authors: Laura K. S. Parnell, Natalie Luke, Mohit Mathur, Richard A. Festa, Emery Haley, Jimin Wang, Yan Jiang, Lori Anderson and David Baunoch.

Quantitative multiplex polymerase chain reaction in copies ml–1 linearly correlates with standard urine culture in colonies ml−1 for urinary tract infection (UTI) pathogens

Letters in Applied Microbiology. Volume 76, Issue 8. Published 27 July, 2023.
Authors: Richard A Festa, Mike Opel, Mohit Mathur, Natalie Luke, Laura K S Parnell, Dakun Wang, Xinhua Zhao, Jesus Magallon, Michael Percaccio, and David Baunoch.

A test combining multiplex-PCR with pooled antibiotic susceptibility testing has high correlation with expanded urine culture for detection of live bacteria in urine samples of suspected UTI patients

Diagnostic Microbiology and Infectious Disease. Volume 107, Issue 2. Published 3 July, 2023.
Authors: Richard A. Festa, Natalie Luke, Mohit Mathur, Laura Parnell, Dakun Wang, Xinhua Zhaob, Jesus Magallona, Marina Remedios-Chan, Jasmine Nguyen, Tim Cho, Annie Ngo, Max Murphy, and David Baunoch.

Multiplex Polymerase Chain Reaction/Pooled Antibiotic Susceptibility Testing Was Not Associated with Increased Antibiotic Resistance in Management of Complicated Urinary Tract Infections

Infection and Drug Resistance. Volume 16. Published 9 May, 2023.
Authors: Howard J Korman, Mohit Mathur, Natalie Luke, Dakun Wang, Xihua Zhao, Michael Levin, David L Wenzler, David Baunoch.

A Diagnostic Test Combining Molecular Testing with Phenotypic Pooled Antibiotic Susceptibility Improved the Clinical Outcomes of Patients with Non-E. coli or Polymicrobial Complicated Urinary Tract Infections

Research and Reports in Urology. Published 1 May, 2023.
Authors: Howard J Korman, David Baunoch, Natalie Luke, Dakun Wang, Xihua Zhao, Michael Levin, David L Wenzler, Mohit Mathur.

The Diagnosis of Urinary Tract Infections Using a Novel At-home Testing Protocol to Enhance Telemedicine: A Retrospective Analysis

Ambulatory, Office-based, and Geriatric Urology. Volume 173. Published 9 January, 2023.
Authors: Andrew Korman, Siddharth Ramanathan, Nathan Shen, Zachary A. Gerndt, Natalie Luke, Dakun Wang, Hannah Zhao, Shuguang Huang, Rajan Dewar, Kirk Wojno, Larry Sirls, Savitha Balaraman, and Howard Korman.

Concordance Between Antibiotic Resistance Genes and Susceptibility in Symptomatic Urinary Tract Infections.

Infection and Drug Resistance. Published 19 August, 2021.
Authors: David BaunochNatalie LukeDakun WangAnnah VollstedtXinhua ZhaoDicken S C KoShuguang HuangPatrick Cacdac, and Larry T Sirls.

After 180 Years, Is it Time for Something Better for Diagnosing UTIs?

JOJ Urology & Nephrology. Volume 7, Issue 3. Published 2 September, 2020.
Authors: Natalie Luke and David Baunoch.

Multisite Prospective Comparison of Multiplex Polymerase Chain Reaction Testing with Urine Culture for Diagnosis of Urinary Tract Infections in Symptomatic Patients

Journal of Surgical Urology, Volume 1, Issue 1, Published 13 July, 2020
Authors: Annah Vollstedt, David Baunoch, Kirk J. Wojno, Natalie Luke, Kevin Cline, Laurence Belkoff, Aaron Milbank, Neil Sherman, Rashel Haverkorn, Natalie Gaines, Neal Shore, Howard Korman, Xinhua Zhao, Shuguang Huang, Mohammad Jafri, Patrick Keating, Bridget Makhlouf, Dylan Hazelton, Stephany Hindo, David Wenzler, Mansour Sabry, Meghan Campbell, Dakun Wang, Larry Sirls.

Bacterial Interactions as Detected by Pooled Antibiotic Susceptibility Testing (P-AST) in Polymicrobial Urine Specimens

Journal of Surgical Urology. Volume 1, Issue 1. Published 29 May, 2020.
Authors: Annah VollstedtDavid BaunochAlan WolfeNatalie LukeKirk J WojnoKevin ClineLaurence BelkoffAaron MilbankNeil ShermanRashel HaverkornNatalie GainesLaurence YoreNeal ShoreMichael OpelHoward KormanColleen KellyMohammad JafriMeghan CampbellPatrick KeatingDylan HazeltonBridget MakhloufDavid WenzlerMansour SabryFrank BurksMiguel PenarandaDavid E SmithPatrick CacdacLarry Sirls.

Utilization of M-PCR and P-AST for Diagnosis and Management of Urinary Tract Infections in Home-Based Primary Care

JOJ Urology & Nephrology. Volume 7, Issue 2. Published 27 March, 2020.
Authors: Annemarie Daly, David Baunoch, Kelly Rehling, Natalie Luke, Meghan Campbell, Patrick Cacdac, Miguel Penaranda, Michael Opel, Shuguang Huang, Xinhua Zhao and Kirk Wojno.

Multiplex PCR Based Urinary Tract Infection (UTI) Analysis Compared to Traditional Urine Culture in Identifying Significant Pathogens in Symptomatic Patients

Urology, 9 November, 2019
Authors: Kirk J Wojno
David BaunochNatalie LukeMichael OpelHoward KormanColleen KellyS Mohammad A JafriPatrick KeatingDylan HazeltonStephany HinduBridget MakhlooufDavid WenzlerMansour SabryFrank BurksMiguel PenarandaDavid E SmithAndrew KormanLarry Sirls. 

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