Guidance® UTI Publications

1. Improving Patient Outcomes While Reducing Empirical Treatment with Multiplex-Polymerase-Chain-Reaction/Pooled-Antibiotic-Susceptibility-Testing Assay for Complicated and Recurrent Urinary Tract Infections

MDPI. Published 26 September 2023.
Authors: Emery Haley, Natalie Luke, Howard Korman, David Baunoch, Dakun Wang, Xinhua Zhao and Mohit Mathur.

2. Real-World Evidence That a Novel Diagnostic Combining Molecular Testing With Pooled Antibiotic Susceptibility Testing is Associated With Reduced Infection Severity and Lower Cost Compared With Standard Urine Culture in Patients With Complicated or Persistently Recurrent Urinary Tract Infections

JU Open Plus. Volume 1 Issue 5. Published 23 May 2023.
Authors: Dicken Ko, Emily Lukacz, Iver Allen Juster, Timothy Niecko, Aparna Ashok, Jean Annah Vollstedt, David Baunoch, Mohit Mathur.

3. Diagnostic Test Combining Molecular Testing with Phenotypic Pooled Antibiotic Susceptibility Improved the Clinical Outcomes of Patients with Non-E. coli or Polymicrobial Complicated Urinary Tract Infections

Research and Reports in Urology. Published 1 May 2023.
Authors: Howard J Korman, David Baunoch, Natalie Luke, Dakun Wang, Xihua Zhao, Michael Levin, David L Wenzler, Mohit Mathur.

4. Multiplex Polymerase Chain Reaction/Pooled Antibiotic Susceptibility Testing Was Not Associated with Increased Antibiotic Resistance in Management of Complicated Urinary Tract Infections

Infection and Drug Resistance. Volume 16. Published 9 May 2023.
Authors: Howard J Korman, Mohit Mathur, Natalie Luke, Dakun Wang, Xihua Zhao, Michael Levin, David L Wenzler, David Baunoch.

5. Utilization of M-PCR and P-AST for Diagnosis and Management of Urinary Tract Infections in Home-Based Primary Care

JOJ Urology & Nephrology. Volume 7, Issue 2. Published 27 March 2020.
Authors: Annemarie Daly, David Baunoch, Kelly Rehling, Natalie Luke, Meghan Campbell, Patrick Cacdac, Miguel Penaranda, Michael Opel, Shuguang Huang, Xinhua Zhao and Kirk Wojno.

6. The Diagnosis of Urinary Tract Infections Using a Novel At-home Testing Protocol to Enhance Telemedicine: A Retrospective Analysis

Ambulatory, Office-based, and Geriatric Urology. Volume 173. Published 9 January 2023.
Authors: Andrew Korman, Siddharth Ramanathan, Nathan Shen, Zachary A. Gerndt, Natalie Luke, Dakun Wang, Hannah Zhao, Shuguang Huang, Rajan Dewar, Kirk Wojno, Larry Sirls, Savitha Balaraman, and Howard Korman.

7. Multiplex PCR Based Urinary Tract Infection (UTI) Analysis Compared to Traditional Urine Culture in Identifying Significant Pathogens in Symptomatic Patients

Urology. Published 9 November 2019.
Authors: Kirk J Wojno, David Baunoch, Natalie Luke, Michael Opel, Howard Korman, Colleen Kelly, S Mohammad A Jafri, Patrick Keating, Dylan Hazelton, Stephany Hindu, Bridget Makhloouf, David Wenzler, Mansour Sabry, Frank Burks, Miguel Penaranda, David E Smith, Andrew Korman, Larry Sirls. 

8. Multisite Prospective Comparison of Multiplex Polymerase Chain Reaction Testing with Urine Culture for Diagnosis of Urinary Tract Infections in Symptomatic Patients

Journal of Surgical Urology. Volume 1, Issue 1, Published 13 July 2020.
Authors: Annah Vollstedt, David Baunoch, Kirk J. Wojno, Natalie Luke, Kevin Cline, Laurence Belkoff, Aaron Milbank, Neil Sherman, Rashel Haverkorn, Natalie Gaines, Neal Shore, Howard Korman, Xinhua Zhao, Shuguang Huang, Mohammad Jafri, Patrick Keating, Bridget Makhlouf, Dylan Hazelton, Stephany Hindo, David Wenzler, Mansour Sabry, Meghan Campbell, Dakun Wang, Larry Sirls.

9. Quantitative multiplex polymerase chain reaction in copies ml^–1 linearly correlates with standard urine culture in colonies ml⁻¹ for urinary tract infection (UTI) pathogens

Letters in Applied Microbiology. Volume 76, Issue 8. Published 27 July 2023.
Authors: Richard A Festa, Mike Opel, Mohit Mathur, Natalie Luke, Laura K S Parnell, Dakun Wang, Xinhua Zhao, Jesus Magallon, Michael Percaccio, and David Baunoch.

10. Elevated UTI Biomarkers in Symptomatic Patients with Urine Microbial Densities of 10,000 CFU/mL Indicate a Lower Threshold for Diagnosing UTIs

Diagnostics. Published 16 August 2023.
Authors: Laura K. S. Parnell, Natalie Luke, Mohit Mathur, Richard A. Festa, Emery Haley, Jimin Wang, Yan Jiang, Lori Anderson and David Baunoch.

11. Comparison Shows that Multiplex Polymerase Chain Reaction Identifies Infection-associated Urinary Biomarker–positive Urinary Tract Infections That Are Missed by Standard Urine Culture

European Urology Open Science. Published December 2023.
Authors: Emery Haley, Natalie Luke, Mohit Mathur, Richard A. Festa, Jimin Wang, Yan Jiang, Lori Anderson, David Baunoch

12. A test combining multiplex-PCR with pooled antibiotic susceptibility testing has high correlation with expanded urine culture for detection of live bacteria in urine samples of suspected UTI patients

Diagnostic Microbiology and Infectious Disease. Volume 107, Issue 2. Published 3 July 2023.
Authors: Richard A. Festa, Natalie Luke, Mohit Mathur, Laura Parnell, Dakun Wang, Xinhua Zhaob, Jesus Magallona, Marina Remedios-Chan, Jasmine Nguyen, Tim Cho, Annie Ngo, Max Murphy, and David Baunoch.

13. The Prevalence and Association of Different Uropathogens Detected by M-PCR with Infection-Associated Urine Biomarkers in Urinary Tract Infections

Research and Reports in Urology. Published 9 January 2024.
Authors: Emery Haley, Natalie Luke, Mohit Mathur, Richard A. Festa, Jimin Wang, Yan Jiang, Lori Anderson, David Baunoch

14. Emerging and Fastidious Uropathogens Were Detected by M-PCR with Similar Prevalence and Cell Density in Catheter and Midstream Voided Urine Indicating the Importance of These Microbes in Causing UTIs

Infection and Drug Resistance. Published 23 December 2023.
Authors: Dakun Wang, Emery Haley, Natalie Luke, Mohit Mathur, Richard A Festa, Xinhua Zhao, Lori A Anderson, Jennifer L Allison, Kristen L Stebbins, Manuel Jose Diaz, David Baunoch

15. Bacterial Interactions as Detected by Pooled Antibiotic Susceptibility Testing (P-AST) in Polymicrobial Urine Specimens

Journal of Surgical Urology. Volume 1, Issue 1. Published 29 May 2020.
Authors: Annah Vollstedt, David Baunoch, Alan Wolfe, Natalie Luke, Kirk J Wojno, Kevin Cline, Laurence Belkoff, Aaron Milbank, Neil Sherman, Rashel Haverkorn, Natalie Gaines, Laurence Yore, Neal Shore, Michael Opel, Howard Korman, Colleen Kelly, Mohammad Jafri, Meghan Campbell, Patrick Keating, Dylan Hazelton, Bridget Makhlouf, David Wenzler, Mansour Sabry, Frank Burks, Miguel Penaranda, David E Smith, Patrick Cacdac, Larry Sirls.

16. Concordance Between Antibiotic Resistance Genes and Susceptibility in Symptomatic Urinary Tract Infections.

Infection and Drug Resistance. Published 19 August 2021.
Authors: David Baunoch, Natalie Luke, Dakun Wang, Annah Vollstedt, Xinhua Zhao, Dicken S C Ko, Shuguang Huang, Patrick Cacdac, and Larry T Sirls.

17. Microbial Threshold Guidelines for UTI Diagnosis: A Scoping Systematic Review

Pathology and Laboratory Medicine International. Published 6 August 2023.
Authors: Evann E Hilt, Laura KS Parnell, Dakun Wang, Ann E Stapleton, and Emily S Lukacz.

18. After 180 Years, Is it Time for Something Better for Diagnosing UTIs?

JOJ Urology & Nephrology. Volume 7, Issue 3. Published 2 September 2020.
Authors: Natalie Luke and David Baunoch.

19. Beyond the Usual Suspects: Emerging Uropathogens in The Microbiome Age

Frontiers in Urology. Published 26 July 2023.
Authors: Robert B. Moreland, Brian I. Choi, Wilson Geaman, Caroline Gonzalez, Baylie R. Hochstedler-Kramer, Jerrin John, Jacob Kaindl, Nikita Kesav, Jyoti Lamichhane, Luke Lucio, Malika Saxena, Aditi Sharma, Lana Tinawi, Michael E. Vanek, Catherine Putonti, Linda Brubaker, and Alan J. Wolfe.

20. Tarnished Gold—The “Standard” Urine Culture: Reassessing The Characteristics of a Criterion Standard for Detecting Urinary Microbes

Frontiers in Urology. Volume 3. Published 11 July 2023.
Authors: Linda Brubaker, Toby C. Chai, Harry Horsley, Rajvinder Khasriya, Robert B. Moreland, and Alan J. Wolfe.

21. Urine Biomarkers Individually and as a Consensus Model Show High Sensitivity and Specificity for Detecting UTIs

BMC Infectious Diseases. Published 31 January 2024.
Authors: Marzieh Akhlaghpour, Emery Haley, Laura Parnell, Natalie Luke, Mohit Mathur, Richard A Festa, Michael Percaccio, Jesus Magallon, Mariana Remedios-Chan, Alain Rosas, Jimin Wang, Yan Jiang, Lori Anderson, David Baunoch