Guidance^® UTI Publications.

Improving Patient Outcomes While Reducing Empirical Treatment with Multiplex-Polymerase-Chain-Reaction/Pooled-Antibiotic-Susceptibility-Testing Assay for Complicated and Recurrent Urinary Tract Infections

MDPI · 26 September 2023

Emery Haley, Natalie Luke, Howard Korman, David Baunoch, Dakun Wang, Xinhua Zhao and Mohit Mathur.

Real-World Evidence That a Novel Diagnostic Combining Molecular Testing With Pooled Antibiotic Susceptibility Testing is Associated With Reduced Infection Severity and Lower Cost Compared With Standard Urine Culture in Patients With Complicated or Persistently Recurrent Urinary Tract Infections

JU Open Plus · 23 May 2023

Dicken Ko, Emily Lukacz, Iver Allen Juster, Timothy Niecko, Aparna Ashok, Jean Annah Vollstedt, David Baunoch, Mohit Mathur.

Diagnostic Test Combining Molecular Testing with Phenotypic Pooled Antibiotic Susceptibility Improved the Clinical Outcomes of Patients with Non-E. coli or Polymicrobial Complicated Urinary Tract Infections

Research and Reports in Urology · 1 May 2023

Howard J Korman, David Baunoch, Natalie Luke, Dakun Wang, Xihua Zhao, Michael Levin, David L Wenzler, Mohit Mathur.

Multiplex Polymerase Chain Reaction/Pooled Antibiotic Susceptibility Testing Was Not Associated with Increased Antibiotic Resistance in Management of Complicated Urinary Tract Infections

Infection and Drug Resistance · 9 May 2023

Howard J Korman, Mohit Mathur, Natalie Luke, Dakun Wang, Xihua Zhao, Michael Levin, David L Wenzler, David Baunoch.

Utilization of M-PCR and P-AST for Diagnosis and Management of Urinary Tract Infections in Home-Based Primary Care

JOJ Urology & Nephrology · 27 March 2020

Annemarie Daly, David Baunoch, Kelly Rehling, Natalie Luke, Meghan Campbell, Patrick Cacdac, Miguel Penaranda, Michael Opel, Shuguang Huang, Xinhua Zhao and Kirk Wojno.

The Diagnosis of Urinary Tract Infections Using a Novel At-home Testing Protocol to Enhance Telemedicine: A Retrospective Analysis

Ambulatory, Office-based, and Geriatric Urology · 9 January 2023

Andrew Korman, Siddharth Ramanathan, Nathan Shen, Zachary A. Gerndt, Natalie Luke, Dakun Wang, Hannah Zhao, Shuguang Huang, Rajan Dewar, Kirk Wojno, Larry Sirls, Savitha Balaraman, and Howard Korman.

Bacterial Interactions as Detected by Pooled Antibiotic Susceptibility Testing (P-AST) in Polymicrobial Urine Specimens

Journal of Surgical Urology · 29 May 2020

Annah Vollstedt,  David Baunoch,  Alan Wolfe,  Natalie Luke,  Kirk J Wojno,  Kevin Cline, et al.

Concordance Between Antibiotic Resistance Genes and Susceptibility in Symptomatic Urinary Tract Infections.

Infection and Drug Resistance · 19 August 2021

David Baunoch, Natalie Luke, Dakun Wang, Annah Vollstedt, Xinhua Zhao, Dicken S C Ko, Shuguang Huang, Patrick Cacdac, and Larry T Sirls.

Pooled Antibiotic Susceptibility Testing Performs Within CLSI Standards for Validation When Measured Against Broth Microdilution and Disk Diffusion Antibiotic Susceptibility Testing of Cultured Isolates

Antibiotics · 14 December 2024

Emery Haley, Frank R. Cockerill, Rick L. Pesano, Richard A. Festa, Natalie Luke, Mohit Mathur, Xiaofei Chen, Jim Havrilla, and David Baunoch.

Pooled Antibiotic Susceptibility Testing for Polymicrobial UTI Performs Within CLSI Validation Standards

Antibiotics · 1 February 2025

Richard A. Festa, Frank R. Cockerill, Rick L. Pesano, Emery Haley, Natalie Luke, Mohit Mathur, et al.

Noninferiority of Multiplex Polymerase Chain Reaction Compared to Standard Urine Culture for Urinary Tract Infection Diagnosis in Pediatric Patients at Hackensack Meridian Health Children’s Hospital Emergency Department

Pediatric Health Med Ther · 22 November 2024

Sejal M Bhavsar, Nisha Polavarapu, Emery Haley, Natalie Luke, Mohit Mathur, Xiaofei Chen, Jim Havrilla, David Baunoch, and Kenneth Lieberman

Urine Biomarkers Individually and as a Consensus Model Show High Sensitivity and Specificity for Detecting UTIs

BMC Infectious Diseases · 31 January 2024

Marzieh Akhlaghpour,  Emery Haley,  Laura Parnell,  Natalie Luke,  Mohit Mathur,  Richard A Festa, et al.

Multiplex PCR Based Urinary Tract Infection (UTI) Analysis Compared to Traditional Urine Culture in Identifying Significant Pathogens in Symptomatic Patients

Kirk J Wojno,  David Baunoch,  Natalie Luke,  Michael Opel,  Howard Korman,  Colleen Kelly, et al.

Multisite Prospective Comparison of Multiplex Polymerase Chain Reaction Testing with Urine Culture for Diagnosis of Urinary Tract Infections in Symptomatic Patients

Annah Vollstedt, David Baunoch, Kirk J. Wojno, Natalie Luke, Kevin Cline, Laurence Belkoff, et al.

Quantitative multiplex polymerase chain reaction in copies ml–1 linearly correlates with standard urine culture in colonies ml−1 for urinary tract infection (UTI) pathogens

Letters in Applied Microbiology · 27 July 2023

Richard A Festa, Mike Opel, Mohit Mathur, Natalie Luke, Laura K S Parnell, Dakun Wang, Xinhua Zhao, Jesus Magallon, Michael Percaccio, and David Baunoch.

Elevated UTI Biomarkers in Symptomatic Patients with Urine Microbial Densities of 10,000 CFU/mL Indicate a Lower Threshold for Diagnosing UTIs

Diagnostics · 16 August 2023

Laura K. S. Parnell, Natalie Luke, Mohit Mathur, Richard A. Festa, Emery Haley, Jimin Wang, Yan Jiang, Lori Anderson and David Baunoch.

Comparison Shows that Multiplex Polymerase Chain Reaction Identifies Infection-associated Urinary Biomarker–positive Urinary Tract Infections That Are Missed by Standard Urine Culture

European Urology Open Science · December 2023

Emery Haley, Natalie Luke, Mohit Mathur, Richard A. Festa, Jimin Wang, Yan Jiang, Lori Anderson, David Baunoch

A test combining multiplex-PCR with pooled antibiotic susceptibility testing has high correlation with expanded urine culture for detection of live bacteria in urine samples of suspected UTI patients

Diagnostic Microbiology and Infectious Disease · 3 July 2023

Richard A. Festa, Natalie Luke, Mohit Mathur, Laura Parnell, Dakun Wang, Xinhua Zhaob, Jesus Magallona, Marina Remedios-Chan, Jasmine Nguyen, Tim Cho, Annie Ngo, Max Murphy, and David Baunoch.

The Prevalence and Association of Different Uropathogens Detected by M-PCR with Infection-Associated Urine Biomarkers in Urinary Tract Infections

Research and Reports in Urology · 9 January 2024

Emery Haley, Natalie Luke, Mohit Mathur, Richard A. Festa, Jimin Wang, Yan Jiang, Lori Anderson, David Baunoch

Emerging and Fastidious Uropathogens Were Detected by M-PCR with Similar Prevalence and Cell Density in Catheter and Midstream Voided Urine Indicating the Importance of These Microbes in Causing UTIs

Infection and Drug Resistance · 23 December 2023

Dakun Wang, Emery Haley, Natalie Luke, Mohit Mathur, Richard A Festa, Xinhua Zhao, Lori A Anderson, Jennifer L Allison, Kristen L Stebbins, Manuel Jose Diaz, David Baunoch

Microbial Threshold Guidelines for UTI Diagnosis: A Scoping Systematic Review

Pathology and Laboratory Medicine International · 6 August 2023

Evann E Hilt, Laura KS Parnell, Dakun Wang, Ann E Stapleton, and Emily S Lukacz.

After 180 Years, Is it Time for Something Better for Diagnosing UTIs?

Natalie Luke and David Baunoch.

Beyond the Usual Suspects: Emerging Uropathogens in The Microbiome Age

Frontiers in Urology · 26 July 2023

Robert B. Moreland, Brian I. Choi, Wilson Geaman, Caroline Gonzalez, Baylie R. Hochstedler-Kramer, Jerrin John, et al.

Tarnished Gold—The “Standard” Urine Culture: Reassessing The Characteristics of a Criterion Standard for Detecting Urinary Microbes

Frontiers in Urology · 11 July 2023

Linda Brubaker, Toby C. Chai, Harry Horsley, Rajvinder Khasriya, Robert B. Moreland, and Alan J. Wolfe.

Comparing Prescribing Behaviors and Clinician Experiences Between Multiplex PCR/Pooled Antibiotic Susceptibility Testing and Standard Urine Culture in Complicated UTI Cases

J Clin Med · 7 December 2024

Emery Haley, Natalie Luke, Howard Korman, Ganesh Srinvas Rao, David Baunoch, Xiaofei Chen, Jim Havrilla and Mohit Mathur