Advanced Prostatitis Testing

Guidance®
Prostatitis.

Advanced diagnostic testing for patients with suspected acute or chronic prostatitis.

PCR organism identification and resistance-gene detection paired with Pooled Antibiotic Susceptibility Testing (P-AST) — accounting for the bacterial interactions in polymicrobial infections that can alter antibiotic resistance.

How Guidance Prostatitis works

PCR sensitivity, susceptibility insight,
one decisive report.

25+3
organisms · bacterial groups

Organism identification (PCR)

Identifies fastidious bacteria and yeasts that are difficult to detect by culture — including organisms commonly implicated in acute and chronic prostatitis.

Faster than culture

Post-massage urine results in less than one day. Semen results within 48 hours.

5
antibiotic-resistance gene classes

Resistance gene detection (PCR)

Targeted PCR amplification detects resistance genes across ampicillin, carbapenem, ESBL, methicillin, and quinolone / fluoroquinolone classes — surfacing genotype context alongside the phenotypic susceptibility profile.

Genotype + phenotype together

Resistance genes reported alongside P-AST to inform first-pass therapy decisions.

Two sample types, fast turnaround. Post-DRE-massage urine results in less than one day from receipt at lab. Semen sample results within 48 hours.
Report Walkthrough

See the report step by step.

A short walkthrough of how the Guidance® report surfaces personalized therapy options from organism detection, resistance-gene presence, and pooled phenotypic susceptibility.

Two sample reports are available — one for voided post-prostatic-massage urine, one for semen.

Post Massage Urine Sample Report Semen Sample Report
From the comfort of home

The same Guidance® results you trust —
delivered to the patient.

For busy schedules, limited mobility, or any reason a sample wasn't left at the office. At-home semen collection kits also offer a comfortable alternative to traditional post-massage urine collection.

  1. 1

    Patient assessment

    The provider determines if Guidance® Prostatitis testing is appropriate for the patient.

  2. 2

    One-step ordering

    The provider completes a Guidance® Prostatitis test requisition and faxes it to Pathnostics.

  3. 3

    Signature service

    Pathnostics calls each patient to review collection instructions, coordinate same-day pickup, and answer questions.

  4. 4

    Fast turnaround

    Once received at the lab, home kits run on the same fast turnaround as in-office samples.

Frequently Asked Questions

Everything your team typically asks.

What organisms does Guidance® Prostatitis test for?

Guidance® Prostatitis uses PCR amplification for the targeted detection of 25 individual organisms and 3 bacterial groups — including fastidious bacteria and yeasts difficult to detect by culture.

Bacterial / yeast organisms
  • Acinetobacter baumannii
  • Actinotignum schaalii
  • Aerococcus urinae
  • Alloscardovia omnicolens
  • Candida albicans
  • Candida auris
  • Candida glabrata
  • Candida parapsilosis
  • Citrobacter freundii
  • Citrobacter koseri
  • Corynebacterium riegelii
  • Enterococcus faecalis
  • Enterococcus faecium
  • Escherichia coli
  • Klebsiella oxytoca
  • Klebsiella pneumoniae
  • Morganella morganii
  • Mycoplasma hominis
  • Proteus mirabilis
  • Providencia stuartii
  • Pseudomonas aeruginosa
  • Serratia marcescens
  • Staphylococcus aureus
  • Streptococcus agalactiae
  • Ureaplasma urealyticum
Bacterial groups
  • Coagulase-negative staphylococci*
  • Viridans group streptococci
  • Enterobacter group
Phenotypic assays
  • ESBL — performed when E. coli, Klebsiella, Enterobacter, Citrobacter, Proteus, Acinetobacter, or Pseudomonas are detected
  • MRSA — performed when S. aureus and the mecA gene are detected

*Coagulase-negative staphylococci: S. epidermidis, S. haemolyticus, S. lugdunensis, S. saprophyticus. Viridans group streptococci: S. anginosus, S. oralis, S. pasteuranus. Enterobacter group: Klebsiella aerogenes (formerly Enterobacter aerogenes), Enterobacter cloacae.

Which antibiotics are included in P-AST?

Guidance® Prostatitis uses dual assessment — genotype resistance and Pooled Antibiotic Susceptibility Testing (P-AST™) — to surface effective, personalized therapy options.

P-AST phenotypic panel
  • Ampicillin (PO/IV)
  • Amoxicillin/Clavulanate (PO)
  • Cefazolin (IM/IV)
  • Cefepime (IV)
  • Ceftazidime (IM/IV)
  • Ceftriaxone (IM/IV)
  • Ciprofloxacin (PO/IV)
  • Doxycycline (PO)
  • Fosfomycin (PO)
  • Gentamicin (IM/IV)
  • Levofloxacin (PO)
  • Linezolid (PO)
  • Meropenem (IV)
  • Piperacillin/Tazobactam (IV)
  • Sulfamethoxazole/Trimethoprim (PO/IV)
  • Tetracycline (PO)
Genotype resistance gene classes
  • Ampicillin
  • Carbapenem
  • Extended-spectrum beta-lactamase (ESBL)
  • Methicillin
  • Quinolone / fluoroquinolone

What is Pooled Antibiotic Susceptibility Testing (P-AST)?

P-AST™ better addresses polymicrobial infections, where bacterial interactions impact antibiotic resistance and sensitivity. Rather than testing each isolated organism in isolation, P-AST™ evaluates how antibiotics perform against the entire pooled infection — closer to the in vivo reality.

Learn More About P-AST

How is a sample collected?

Two collection options are supported: a voided post-DRE prostatic massage urine sample, or a semen sample. Collection-instruction videos are available on request — for at-home collection, every patient receives a signature-service call walking them through the process.

Ready to put precision at the point of decision?

Guidance® Prostatitis helps clinicians move from trial-and-error toward better-informed first-pass therapy.

References
  1. Jarvi K, Lacroix J-M, Jain A, et al. Polymerase chain reaction-based detection of bacteria in semen. Fertil Steril. 1996;66:463–467. DOI: 10.1016/s0015-0282(16)58520-3

When specimen is collected as instructed.