Pooled antibiotic susceptibility testing that evaluates how antibiotics perform against the infection as a whole — including in polymicrobial cases. Results in 24–36 hours.
More informed treatment decisions for complicated, recurrent, or persistent UTIs.
Precision diagnostic testing that combines molecular detection with proprietary pooled phenotypic antibiotic susceptibility testing. Results in less than one day from receipt at lab.†
Identifies commonly tested uropathogens including fastidious bacteria and yeasts that are difficult to detect by culture, developed using an evidence-based analysis of uropathogens.
95% sensitivity identifying organisms — 43% more sensitive than culture.1
Targeted PCR amplification detects resistance genes across six antibiotic classes — including ampicillin, carbapenem, ESBL, methicillin, fluoroquinolone, and vancomycin resistance.
Identifies specific pathogens even in polymicrobial infections, which occur in up to 52% of positive cases.1
Evaluates how 20 antibiotics actually perform against the patient's infection as a whole, accounting for bacterial interactions in polymicrobial cases that may alter resistance and sensitivity.2,3
Surfaces personalized therapy options informed by phenotypic susceptibility, not just genotype.
Guidance® UTI testing is associated with measurable improvements in critical clinical and economic outcomes for complicated UTI (cUTI).
Study: Standard urine culture (N=678) vs Guidance® UTI (N=69)4
Reference: Aparna Ashok, Dicken Ko (Providence, RI); Emily Lukacz (La Jolla, CA); Annah Vollstedt (Iowa City, IA); Iver Juster (San Rafael, CA); Timothy Niecko (Tierra Verde, FL); David Baunoch (Trabuco Canyon, CA); Mohit Mathur (Irvine, CA). Comparison of Guidance® UTI and standard urine culture for rates of sepsis, hospitalization and other adverse outcomes in complicated urinary tract infections [abstract]. Journal of Urology. AUA Annual Meeting Program Abstracts 2022. 1 May 2022. Volume 207, Issue Supplement 5.
Two pages. Personalized therapy options surfaced from organism detection, resistance-gene presence, and phenotypic susceptibility. Designed for fast, confident clinical decisions.
For busy schedules, limited mobility, or any reason a sample wasn't left at the office, Guidance® UTI from home keeps care moving without the office visit.
The provider determines if Guidance® UTI is appropriate for the patient.
The provider completes a Guidance® UTI test requisition and faxes it to Pathnostics.
Pathnostics calls each patient to review collection instructions, coordinate same-day pickup, and answer questions.
Once received at the lab, home kits run on the same less-than-one-day† turnaround as in-office samples.
Guidance® UTI uses PCR amplification for the targeted detection of 26 individual organisms and 3 bacterial groups. Pathogens are reported in ranges of organism(s) per milliliter of urine.
*Coagulase-negative staphylococci: S. epidermidis, S. haemolyticus, S. lugdunensis, S. saprophyticus. †Viridans group streptococci: S. anginosus, S. oralis, S. pasteuranus. ‡Enterobacter group: Klebsiella aerogenes (formerly Enterobacter aerogenes), Enterobacter cloacae.
Guidance® UTI is the only advanced UTI test with robust peer-reviewed clinical evidence supporting its use across post-acute, urology, gynecology, primary care, urgent care, and at-home settings.
View All Peer-Reviewed Publications →Guidance® UTI uses dual assessment — genotype resistance and Pooled Antibiotic Susceptibility Testing (P-AST™) — to surface effective, personalized therapy options.
P-AST™ better addresses polymicrobial infections, where bacterial interactions impact antibiotic resistance and sensitivity. Rather than testing each isolated organism in isolation, P-AST™ evaluates how antibiotics perform against the entire pooled infection — closer to the in vivo reality.
Learn More About P-AST™ →Sample collection follows standard mid-stream clean-catch protocol. For provider-office collection, an instructional video is available on request. For at-home collection, every patient receives a signature-service call walking them through the process.
Guidance® UTI helps clinicians move from trial-and-error toward better-informed first-pass therapy.
†When specimen is collected as instructed.
