E. faecium

Emery Haley, PhD, Scientific Writing Specialist

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Clinical Summary

C. koseri is recognized as a classical gram-negative, urease-variable, biofilm-forming uropathogen. 
C. koseri is associated with complicated UTI in older adult and pediatric populations. 
In symptomatic UTI patients, C. koseri: 
- Is not a contaminant (is found in catheter-collected urine specimens). 
- Is viable (can grow out on culture). 
- Is pathogenic (associated with elevated urine biomarkers of infection). 
Reported severe complications of C. koseri UTI include pyelonephritis, polymicrobial bacteremia, and urosepsis. 
Multidrug-resistant C. koseri (especially among hospital-acquired UTIs) is a significant global health threat.

Bacterial Characteristics

Gram-stain

Gram-negative

Morphology

Bacillus

Growth Requirements

Non-fastidious (grows well in standard urine culture conditions)
Facultative anaerobe

Nitrate Reduction

Yes

Urease

Variable

Biofilm Formation

Yes

Pathogenicity

Colonizer or Pathobiont

Clinical Relevance in UTI

C. koseri is a urease-variable microorganism [1] capable of forming biofilms. C. koseri is typically considered to be among the common classical uropathogens in older adults,[2]  but is also being increasingly recognized as common in pediatric UTIs.[3]

In a study of older adult males and females with clinically suspected complicated UTI, C. koseri was detected in both midstream voided and in-and-out-catheter collected specimens indicating that it was truly present in the bladder, not simply a contaminant picked up during voiding.[4]  Furthermore, elevated markers of immune system activation in the urinary tract have been measured from the same clinical urine specimens in which C. koseri was detected, indicating that the presence of C. koseri was associated with an immune response to urinary tract infection.[5–7]   Hospital-acquired C. koseri UTIs pose a particularly serious threat, as these infections increasingly display multidrug- or pandrug-resistance.[8]  Severe complications of C. koseri UTI, including pyelonephritis, polymicrobial bacteremia, and urosepsis, have been reported.[9–11]

Hospital-acquired C. koseri UTIs pose a particularly serious threat, as these infections increasingly display multidrug- or pandrug-resistance.[8]  Although not considered one of the six highest priority “ESKAPE” pathogens, The World Health Organization (WHO) has included this organism in the 2024 Bacterial Priority Pathogens List (BPPL).[111] Severe complications of C. koseri UTI, including pyelonephritis, polymicrobial bacteremia, and urosepsis, have been reported.[9–11] 

Together, these findings indicate that C. koseri should be seriously considered as a uropathogen and demonstrate the value of detecting this organism, particularly in individuals with recurrent UTI and/or risk factors for persistent or complicated UTI.

Treatment

Evidence of Efficacy (Checkmarks): Amoxicillin/Clavulanate, Ampicillin/Sulbactam, Cefaclor, Cefazolin, Cefepime, Cephalexin, Ceftazidime, Ceftriaxone, Ciprofloxacin, Gentamicin, Levofloxacin, Meropenem, Nitrofurantoin, Piperacillin/Tazobactam, Sulfamethoxazole/Trimethoprim, and Trimethoprim.

References

1. Khalil, M.A.; Alorabi, J.A.; Al-Otaibi, L.M.; Ali, S.S.; Elsilk, S.E. Antibiotic Resistance and Biofilm Formation in Enterococcus Spp. Isolated from Urinary Tract Infections. Pathogens 2022, 12, 34, doi:10.3390/pathogens12010034.
2. BacDive | The Bacterial Diversity Metadatabase Available online: https://bacdive.dsmz.de/ (accessed on 11 February 2025).
3. BioCyc Pathway/Genome Database Collection Available online: https://biocyc.org/ (accessed on 11 February 2025).
4. Xu, W.; Fang, Y.; Zhu, K. Enterococci Facilitate Polymicrobial Infections. Trends Microbiol. 2024, 32, 162–177, doi:10.1016/j.tim.2023.07.010.
5. Laliany, G.; Jamehdar, S.A.; Makhdoumi, A. In Vitro Virulence Activity of Pseudomonas Aeruginosa, Enhanced by Either Acinetobacter Baumannii or Enterococcus Faecium through the Polymicrobial Interactions. Arch. Microbiol. 2022, 204, 709, doi:10.1007/s00203-022-03308-8.
6. Coman, F.; Codău, C.-A.; Novac, B. Breaking the Stone and Beating the Bug: Managing Ureterolithiasis with Enterococcus Faecium in a High-Risk Patient. Arch. Clin. Cases 2025, 12, 51–53, doi:10.22551/2025.46.1201.10312.
7. Eure, T.R.; Stone, N.D.; Mungai, E.A.; Bell, J.M.; Thompson, N.D. Antibiotic-Resistant Pathogens Associated with Urinary Tract Infections in Nursing Homes: Summary of Data Reported to the National Healthcare Safety Network Long-Term Care Facility Component, 2013–2017. Infect. Control Hosp. Epidemiology 2021, 42, 31–36, doi:10.1017/ice.2020.348.
8. Kraszewska, Z.; Skowron, K.; Kwiecińska-Piróg, J.; Grudlewska-Buda, K.; Przekwas, J.; Wiktorczyk-Kapischke, N.; Wałecka-Zacharska, E.; Gospodarek-Komkowska, E. Antibiotic Resistance of Enterococcus Spp. Isolated from the Urine of Patients Hospitalized in the University Hospital in North-Central Poland, 2016–2021. Antibiotics 2022, 11, 1749, doi:10.3390/antibiotics11121749.
9. Georges, M.; Odoyo, E.; Matano, D.; Tiria, F.; Kyany’a, C.; Mbwika, D.; Mutai, W.C.; Musila, L. Determination of Enterococcus Faecalis and Enterococcus Faecium Antimicrobial Resistance and Virulence Factors and Their Association with Clinical and Demographic Factors in Kenya. J. Pathog. 2022, 2022, 3129439, doi:10.1155/2022/3129439.
10. Ahmed, J.; Yadav, R.K.; Sood, S.; Das, B.K.; Dhawan, B. Vancomycin-Resistant Enterococcus Faecium: A High Priority Pathogen. J. Appl. Sci. Clin. Pr. 2023, 4, 168–176, doi:10.4103/jascp.jascp_17_23.
11. Wang, D.; Haley, E.; Luke, N.; Mathur, M.; Festa, R.; Zhao, X.; Anderson, L.A.; Allison, J.L.; Stebbins, K.L.; Diaz, M.J.; et al. Emerging and Fastidious Uropathogens Were Detected by M-PCR with Similar Prevalence and Cell Density in Catheter and Midstream Voided Urine Indicating the Importance of These Microbes in Causing UTIs. Infect. Drug Resist. 2023, Volume 16, 7775–7795, doi:10.2147/idr.s429990.
12. Haley, E.; Luke, N.; Mathur, M.; Festa, R.A.; Wang, J.; Jiang, Y.; Anderson, L.A.; Baunoch, D. The Prevalence and Association of Different Uropathogens Detected by M-PCR with Infection-Associated Urine Biomarkers in Urinary Tract Infections. Res. Rep. Urol. 2024, 16, 19–29, doi:10.2147/rru.s443361.
13. Akhlaghpour, M.; Haley, E.; Parnell, L.; Luke, N.; Mathur, M.; Festa, R.A.; Percaccio, M.; Magallon, J.; Remedios-Chan, M.; Rosas, A.; et al. Urine Biomarkers Individually and as a Consensus Model Show High Sensitivity and      Specificity for Detecting UTIs. BMC Infect Dis 2024, 24, 153, doi:10.1186/s12879-024-09044-2.
14. Parnell, L.K.D.; Luke, N.; Mathur, M.; Festa, R.A.; Haley, E.; Wang, J.; Jiang, Y.; Anderson, L.; Baunoch, D. Elevated UTI Biomarkers in Symptomatic Patients with Urine Microbial Densities of 10,000 CFU/ML Indicate a Lower Threshold for Diagnosing UTIs. MDPI 2023, 13, 1–15, doi:10.3390/diagnostics13162688.
15. Miller, W.R.; Arias, C.A. ESKAPE Pathogens: Antimicrobial Resistance, Epidemiology, Clinical Impact and Therapeutics. Nat. Rev. Microbiol. 2024, 22, 598–616, doi:10.1038/s41579-024-01054-w.
16. Wu, Y.; Li, P.; Huang, Z.; Liu, J.; Yang, B.; Zhou, W.; Duan, F.; Wang, G.; Li, J. Four-Year Variation in Pathogen Distribution and Antimicrobial Susceptibility of Urosepsis: A Single-Center Retrospective Analysis. Ther. Adv. Infect. Dis. 2024, 11, 20499361241248056, doi:10.1177/20499361241248058.
17. Parente, G.; Gargano, T.; Pavia, S.; Cordola, C.; Vastano, M.; Baccelli, F.; Gallotta, G.; Bruni, L.; Corvaglia, A.; Lima, M. Pyelonephritis in Pediatric Uropathic Patients: Differences from Community-Acquired Ones and Therapeutic Protocol Considerations. A 10-Year Single-Center Retrospective Study. Children 2021, 8, 436, doi:10.3390/children8060436.
18. Shahab, K.; Mufti, A.Z.; Iqbal, M.A.; Roghani, M.; Zeb, F.; Amin, U. Assessment of Microbial Diversity Pattern of Sensitivity and Antimicrobial Susceptibility in Patients Admitted with Urosepsis. Ann. PIMS-Shaheed Zulfiqar Ali Bhutto Méd. Univ. 2023, 19, 339–345, doi:10.48036/apims.v19i3.924.

About the Author

Dr. Emery Haley is a scientific writing specialist with over ten years of experience in translational cell and molecular biology. As both a former laboratory scientist and an experienced science communicator, Dr. Haley is passionate about making complex research clear, approachable, and relevant. Their work has been published in over 10 papers and focuses on bridging the gap between the lab and real-world patient care to help drive better health outcomes.

Urologists

Primary Care Physicians

Gastroenterologists

Gynecologists

Medical Directors

Post-Acute Care

Healthcare at Home

Urology Clinic

Immediate Care/Urgent Care

Telemedicine

E. faecium

CHECK BACK SOON FOR OUR FULL BLOG ON THE IMPORTANCE OF ENTEROCOCCUS FAECIUM

Clinical Summary

Bacterial Characteristics

Gram-stain

Morphology

Growth Requirements

Nitrate Reduction

Urease

Biofilm Formation

Pathogenicity

Clinical Relevance in UTI

Treatment

References

About the Author

Urologists

Primary Care Physicians

Gastroenterologists

Gynecologists

Medical Directors

Post-Acute Care

Healthcare at Home

Urology Clinic

Immediate Care/Urgent Care

Telemedicine

CHECK BACK SOON FOR OUR FULL BLOG ON THE IMPORTANCE OF ENTEROCOCCUS FAECIUM

Clinical Summary

Bacterial Characteristics

Gram-stain

Morphology

Growth Requirements

Nitrate Reduction

Urease

Biofilm Formation

Pathogenicity

Clinical Relevance in UTI

Treatment

References

About the Author

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